Relationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivo

Relationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivo

Source :

• The Journal of Gene Medicine [ 1099-498X ] ; 2003-02.

Descripteurs français

• KwdFr :
  • ADN (), ADN (métabolisme), Adjuvants pharmaceutiques (), Adjuvants pharmaceutiques (métabolisme), Animaux, Chitine (), Chitine (analogues et dérivés), Chitine (métabolisme), Chitosane, Chlorure de sodium (), Concentration en ions d'hydrogène, Conformation d'acide nucléique, Expression des gènes, Gènes rapporteurs, Humains, Lignée cellulaire, Masse moléculaire, Polymères (), Polymères (métabolisme), Souris, Structures macromoléculaires, Techniques de transfert de gènes.
• MESH :
  • analogues et dérivés : Chitine.
  • métabolisme : ADN, Adjuvants pharmaceutiques, Chitine, Polymères.
  • ADN, Adjuvants pharmaceutiques, Animaux, Chitine, Chitosane, Chlorure de sodium, Concentration en ions d'hydrogène, Conformation d'acide nucléique, Expression des gènes, Gènes rapporteurs, Humains, Lignée cellulaire, Masse moléculaire, Polymères, Souris, Structures macromoléculaires, Techniques de transfert de gènes.

English descriptors

• KwdEn :
  • Adjuvants, Pharmaceutic (chemistry), Adjuvants, Pharmaceutic (metabolism), Animals, Cell Line, Chitin (analogs & derivatives), Chitin (chemistry), Chitin (metabolism), Chitosan, DNA (chemistry), DNA (metabolism), Gene Expression, Gene Transfer Techniques, Genes, Reporter, Humans, Hydrogen-Ion Concentration, Macromolecular Substances, Mice, Molecular Weight, Nucleic Acid Conformation, Polymers (chemistry), Polymers (metabolism), Sodium Chloride (chemistry).
• MESH :
  • chemical , analogs & derivatives : Chitin.
  • chemical , chemistry : Adjuvants, Pharmaceutic, Chitin, DNA, Polymers, Sodium Chloride.
  • chemical , metabolism : Adjuvants, Pharmaceutic, Chitin, DNA, Polymers.
• Teeft :
  • Acetate buffer, Acetylation, Aggregation, Animals, Assay, Cationic, Cell Line, Chain length, Charge ratio, Charge ratios, Chitosan, Chitosan chain length, Chitosan complexes, Chitosan oligomer, Chitosan oligomers, Chitosans, Cooperative effect, Copyright, Deionized, Deionized water, Gene, Gene Expression, Gene Transfer Techniques, Gene delivery, Gene delivery system, Gene delivery systems, Gene expression, Genes, Reporter, Globular, Globular structures, Globule, Humans, Hydrogen-Ion Concentration, Intratracheal administration, Ionic strength, John wiley sons, Luciferase, Luciferase gene expression, Luciferase reporter, Luciferase reporter gene, Lung protein, Macromolecular Substances, Mice, Molecular Weight, Molecular weight, Molecular weight chitosans, Monomer units, Mouse lungs, Nonviral, Nonviral gene delivery system, Nonviral gene delivery systems, Nucleic Acid Conformation, Oligomer, Oligomer concentration, Oligomers, Pdna, Pdna complexes, Physical shape, Physical stability, Plasmid, Positive charges, Previous studies, Retardation assay, Size distribution, Soluble, Soluble globules, Solvent properties, Stable complexes, Standard deviation, Transfection, Uorescence, Uorescence microscopy, Vivo, Weight chitosan, Weight chitosans.

Abstract

• https://api.istex.fr/ark:/67375/WNG-M7LCGCD1-9/fulltext.pdf

Affiliations:

• Norvège, Suède
• East Middle Sweden, Svealand, Trøndelag
• Trondheim, Uppsala
• Université d'Uppsala

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